PD-1-inhibitor pembrolizumab for treatment of progressive multifocal leukoencephalopathy
The reactivation of human JC polyoma virus (JCPyV) results in lytic infection of oligodendrocytes and neuronal cells.The corresponding clinical picture is called progressive multifocal leukoencephalopathy (PML) and results mostly from a disease-related or drug-induced immunosuppression.The opportunistic brain infection leads to a progressive demyel